Lithium cadmate-mediated deprotonative metalation of anisole: experimental and computational study.
نویسندگان
چکیده
Lithium cadmates bearing different ligands were compared with efficient (TMP)(3)CdLi (TMP = 2,2,6,6-tetramethylpiperidino) for their ability to deprotometalate anisole. The generated arylcadmates were evidenced using I(2). The results show that it is possible to replace only one of the TMP (with a piperidino, a diisopropylamino, a butyl, or a sec-butyl) without important yield drop. In the light of DFT calculations, reaction pathways were proposed for the deprotocadmations of anisole using a triamino, an alkyldiamino, and an aminodialkyl cadmate.
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 75 9 شماره
صفحات -
تاریخ انتشار 2010